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Old 7 Jun 2008, 7:47 PM   #1 (permalink)
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Quinine

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How does quinine work against malaria?
Specifically, not just that it intereferes with the plasmodium lifecycle
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Old 9 Jun 2008, 9:04 AM   #2 (permalink)
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Re: Quinine

Tell me about its chemical composition first.
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Old 23 Nov 2008, 9:33 PM   #3 (permalink)
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Re: Quinine

Quinine works against Plasmodia falciparum (and I suppose other Plasmodia) by preventing the Plasmodia from protecting itself against haem. Haem, which is a byproduct of the breakdown of haemoglobin, which Plasmodia consume, is poisonous and so Plasmodia store this in a vacuole, so they can transform it into harmless haemazoin. Quinine however, interferes with the storage of haem (but I couldn't find exactly how it does that) so that it remains in the cell, poisoning, and, eventually, killing it.

Hope that helped.
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