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| feel like an angel HSC: 2008 Gender: Female
Join Date: Mar 2007
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17 Jul 2009, 11:09 PM ![]() | Quinine You can hide this advertisement by registering. How does quinine work against malaria?Specifically, not just that it intereferes with the plasmodium lifecycle |
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| | #2 (permalink) |
| Self-delusive HSC: 2008 Gender: Male
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16 Jul 2009, 10:43 PM ![]() | Re: Quinine Tell me about its chemical composition first.
__________________ BPharmacy @ Usyd Class' 2013 When I was a child I caught a fleeting glimpse. Out of the corner of my eyes I turned to see but it was gone I cannot put my finger on it now The child is grown, the dream is gone... (Confortably numb - Pink Floyd) |
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| | #3 (permalink) |
| New Member HSC: 2009 Gender: Male
Join Date: Nov 2008
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9 Aug 2009, 4:50 PM ![]() | Re: Quinine Quinine works against Plasmodia falciparum (and I suppose other Plasmodia) by preventing the Plasmodia from protecting itself against haem. Haem, which is a byproduct of the breakdown of haemoglobin, which Plasmodia consume, is poisonous and so Plasmodia store this in a vacuole, so they can transform it into harmless haemazoin. Quinine however, interferes with the storage of haem (but I couldn't find exactly how it does that) so that it remains in the cell, poisoning, and, eventually, killing it. Hope that helped. |
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