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**Survivor39** · 9 Dec 2006, 2:57 PM

No. Therapeutic DNA doesn't really have anything to do with DNA splicing. DNA splicing is the process of removing introns from the primary transcript, to form an mRNA.

Although I'm not sure of the exact mechanism of how this particular therapeutic DNA works, generally the theapeutic DNA may be inserted close to the promoter of the IL-1 gene, and disrupt its expression. Alternatively, it is possible that the theapuetic DNA may be inserted into the host genome that are then expressed, yielding a protein that bind to the IL-1 gene, or the IL-1 protein, therefore, preventing the function of IL-1.

9 Dec 2006, 2:57 PM	#2 (permalink)
Survivor39 Moderator HSC: 2003 Gender: Undisclosed Join Date: May 2003 Posts: 4,330 Last Activity: Today, 4:31 AM	Re: Gene Splicing No. Therapeutic DNA doesn't really have anything to do with DNA splicing. DNA splicing is the process of removing introns from the primary transcript, to form an mRNA. Although I'm not sure of the exact mechanism of how this particular therapeutic DNA works, generally the theapeutic DNA may be inserted close to the promoter of the IL-1 gene, and disrupt its expression. Alternatively, it is possible that the theapuetic DNA may be inserted into the host genome that are then expressed, yielding a protein that bind to the IL-1 gene, or the IL-1 protein, therefore, preventing the function of IL-1. __________________ PhD, University of Cambridge, 09-12 MSc, UNSW, 08-09 BMedSc (Hons I), UNSW, 04-07