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brenton1987 · 5 Sep 2007, 8:32 PM

It's easier to understand if you take in glycolysis as well, because it shows where the Acetyl-CoA comes from.

Glycolysis
Glucose + ATP --> Glucose-6-phosphate + ADP
Glucose-6-phosphate --> Fructose-6-phosphate
Frucose-6-phosphate + ATP --> Fructose-1,6-bisphosphate
Fructose-1,6-bisphosphate --> Dihydroxyacetonephosphate + Glyceraldehyde-3-phosphate
Dihydroxyacetonephosphate + Glyceraldehyde-3-phosphate --> 2 Glyceraldehyde-3-phosphate
2 Glyceraldehyde-3-phosphate + NAD⁺ + P_i --> 2 1,3-Bisphosphoglycerate + NADH + H⁺
2 1,3-Bisphosphoglycerate + ADP --> 2 3-Phosphoglycerate + ATP
2 3-Phosphoglycerate --> 2 2-Phosphoglycerate
2 2-Phosphoglycerate --> 2 Phosphoenolpyruvate + H₂O
2 Phosphoenolpyruvate + ADP --> 2 Pyruvate + ATP
2 Pyruvate + CoA + NAD⁺ --> 2 Acetyl-CoA + NADH + H⁺ + CO₂

Overall Reaction
Glucose + 2NAD⁺ + P_i + CoA --> 2 Acetyl-CoA + 2NADH + 2H⁺ + H₂O + CO₂

Krebs Cycle
Oxaloacetate + Acetyl-CoA --> Citrate + CoA
Citrate --> cis-Aconitate + H₂O
cis-Aconitate + H₂O --> Isocitrate
Isocitrate + NAD⁺ --> Oxalosuccinate + NADH + H⁺
Oxalosuccinate --> a-Ketoglutarate + CO₂
a-Ketoglutarate + CoA + NAD⁺ --> Succinyl-CoA + NADH + H⁺ + CO₂
Succinyl-CoA + GDP + P_i --> Succinate + GTP + CoA
Succinate + FAD --> Fumarate + FADH
Fumarate + H₂O --> Malate
Malate + NAD⁺ --> Oxaloacetate + NADH + H⁺

Overall Reaction
Acetyl-CoA + 3NAD⁺ + FAD + GDP + P_i + H₂O --> 3NADH + FADH + 3H⁺ + 2CO₂ + GTP + 2CoA

5 Sep 2007, 8:32 PM	#4 (permalink)
brenton1987 Senior Member HSC: 2005 Gender: Male Location: Newcastle Join Date: Jun 2004 Posts: 242 Last Activity: Yesterday, 6:45 PM	Re: Krebs cycle? It's easier to understand if you take in glycolysis as well, because it shows where the Acetyl-CoA comes from. Glycolysis Glucose + ATP --> Glucose-6-phosphate + ADP Glucose-6-phosphate --> Fructose-6-phosphate Frucose-6-phosphate + ATP --> Fructose-1,6-bisphosphate Fructose-1,6-bisphosphate --> Dihydroxyacetonephosphate + Glyceraldehyde-3-phosphate Dihydroxyacetonephosphate + Glyceraldehyde-3-phosphate --> 2 Glyceraldehyde-3-phosphate 2 Glyceraldehyde-3-phosphate + NAD⁺ + P_i --> 2 1,3-Bisphosphoglycerate + NADH + H⁺ 2 1,3-Bisphosphoglycerate + ADP --> 2 3-Phosphoglycerate + ATP 2 3-Phosphoglycerate --> 2 2-Phosphoglycerate 2 2-Phosphoglycerate --> 2 Phosphoenolpyruvate + H₂O 2 Phosphoenolpyruvate + ADP --> 2 Pyruvate + ATP 2 Pyruvate + CoA + NAD⁺ --> 2 Acetyl-CoA + NADH + H⁺ + CO₂ Overall Reaction Glucose + 2NAD⁺ + P_i + CoA --> 2 Acetyl-CoA + 2NADH + 2H⁺ + H₂O + CO₂ Krebs Cycle Oxaloacetate + Acetyl-CoA --> Citrate + CoA Citrate --> cis-Aconitate + H₂O cis-Aconitate + H₂O --> Isocitrate Isocitrate + NAD⁺ --> Oxalosuccinate + NADH + H⁺ Oxalosuccinate --> a-Ketoglutarate + CO₂ a-Ketoglutarate + CoA + NAD⁺ --> Succinyl-CoA + NADH + H⁺ + CO₂ Succinyl-CoA + GDP + P_i --> Succinate + GTP + CoA Succinate + FAD --> Fumarate + FADH Fumarate + H₂O --> Malate Malate + NAD⁺ --> Oxaloacetate + NADH + H⁺ Overall Reaction Acetyl-CoA + 3NAD⁺ + FAD + GDP + P_i + H₂O --> 3NADH + FADH + 3H⁺ + 2CO₂ + GTP + 2CoA Last edited by brenton1987; 5 Sep 2007 at 9:01 PM.