Analyse the effect of high mutation rates of viruses on human health as well as the survival of the virus. 7 marks
This question is basically 2005 HSC Q27 slightly re-worded and without the background information given about the influenza virus. Anyway, I'll take a shot at answering the HSC question:
27. The influenza virus has a high rate of mutation which can lead to changes of the viral
surface antigens that contain protein. Analyse the impact of high mutation rates for this virus and the implications for
human health (8 marks).
- A viral pathogen such as the influenza virus is engulfed by a macrophage and it’s surface antigen is transported to a lymph node to be presented to a helper T cell. Here, the helper T cell ‘sensitises’ B cells to the pathogen. The B cells then clone and differentiate into plasma B cells and memory B cells. The plasma B cells manufacture antibodies which are specific to the virus, which then bind to the viral antigens and neutralise them, allowing cytotoxic T cells to directly destroy them. The role of the memory B cells is to respond rapidly in the event of a second infection by the same virus.
- If this happens, they clone rapidly to make plasma B cells and the immune response (secondary response) is faster and of greater magnitude than the primary (first) response. This will generally prevent the host from suffering from the disease a second time.
- However, with rapidly mutating viruses such as the influenza virus, the viral surface antigens would have changed to the point where the memory B cells don’t recognise it and don’t trigger the secondary immune response. Therefore the host experiences the virus’s symptoms once again while the mutated viral pathogen survives until the host's immune system initiates another primary response against it.
- In today’s society most countries have a seasonal-flu vaccine, however since the influenza virus constantly mutates a new version has to be developed each year or so, an expensive process which can takes months. This time lag could be potentially deadly to overall human health if there were ever to be a severe influenza pandemic in which the virus spread rapidly around the world, since humans have little to no immune protection against new flu strains.