I would have to say from experiance and seeing many others. No it doesn't work. Well, usually not in 90% of circumstances, I'm sure there are exceptions.
I'll agree it's possible for them to be just friends, but never really anything close to best friends. Allways feelings (either positive or negative) or wants from either side that the other doesn't want.
Honestly I don't think I have ever seen a situation where it is a guy and a girl who truely just want to hang out with each other constantly, in the same way I do with my best friends. Usually the one of them is fairly annoyed at how much the other is always around, or one of them wants something more from the other one.
I'm sure examples will be provided to the otherwise, but in 90% of cases, this is how it ends up.